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In the work presented in this paper, a Web-based, grid-enabled environment for wideband code-division multiple-access (WCDMA) system simulations has been implemented and evaluated. The increasing demands for computation times as the complexity of the simulation increases (e.g., increased sectorization order, smart antennas, etc., or combining system with link-level simulations) soon become prohibitively high. A WCDMA simulation is essentially a Monte Carlo simulation, consisting of a large number of identical and independent processes, which are viable for efficient and cost-effective distributed processing on a grid infrastructure. In the work presented herein, a problem-solving environment (PSE) has been implemented for grid-enabled execution of WCDMA simulations on the production grid infrastructure deployed by the Enabling Grids for E-sciencE (EGEE) project. The problem-solving environment provides a secure, Web-based portal for interacting with the grid middleware (e.g., job submission and monitoring, result retrieval, etc.). The grid-enabled simulator is presented, and implementation details are discussed. Simulation results and grid execution statistics are also shown, in order to demonstrate the validity of the approach.